Upper GI endoscopy and timed barium oesophagogram are the initial investigations to rule out mechanical obstruction
High resolution manometry (HRM) is diagnostic and helps to classify achalasia
Upper Gastrointestinal Endoscopy
Endoscopy in achalasia shows a dilated and tortuous oesophagus and intermittent tertiary contractions
A pulsion-type oesophageal epiphrenic pseudodiverticulum can be seen
Timed Barium Oesophagogram
Timed barium oesophagogram (TBE) is the imaging of choice in achalasia
Delayed emptying of the barium from the oesophagus, tertiary contractions, and bird-beak appearance on the X-ray are the characteristic features
In late stages of achalasia, megaoesophagus (oesophageal diameter: >7 cm) and sigmoid oesophagus (dilated, tortuous oesophagus) can be seen
High-Resolution Manometry
Classifies achalasia cardia
Type I achalasia
- no oesophageal contractility or pressurization
- represents late-stage disease with a dilated, atonic oesophagus
Type II Achalasia
- characterised by panoesophagael pressurisation (in >20% swallows) between the upper and lower oesophageal sphincter
- Type II AC represents the early stage of disease
- most responsive to pneumatic dilatation (PD)
- Type II achalasia is also the most common subtype
Type III Achalasia
- least common
- least responsive to therapy
Management
In patients with low surgical risk, pneumatic dilatation, laparoscopic Heller’s myotomy (LHM), or POEM are the mainstays of treatment
Botulinum toxin (BT)/pharmacotherapy is reserved for patients with high surgical risk/limited life expectancy.
Botulinum Toxin
- The effect of therapy is short lived
- 50% of patients require reinjection after 6–12 months
- Repeat injections can be technically difficult because of fibrosis from prior injections.
Pharmacological Therapy
calcium channel blockers, nitrates, anticholinergics, phosphodiesterase inhibitors, and β agonists have been tested in achalasia
provide short-lived benefits at most
Pneumatic Dilatation
Rigiflex™ balloon dilator available in three sizes: 30, 35, and 40 mm, is used for performing PD
Initially, the 30 mm balloon is used, followed by progressively larger balloons (the graded approach)
After index dilatation by the graded approach, repeated dilatations on follow-up for recurrent symptoms is known as the ‘on demand approach’.
Peroral Endoscopic Myotomy
It is useful in treatment naïve, treatment failure, and Type III achalasia.
A contrast oesophagogram is carried out at postoperative Day 1 to exclude a possible leak and to evaluate the treatment response by seeing adequacy of barium emptying
Laparoscopic Heller’s Myotomy
LHM is the first-line surgical therapy for achalasia
a response rate of 90–97%
The minimally invasive, laparoscopic approach is associated with shorter hospital stays, reduced postoperative pain, and lower disability